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The t(9;22)(q34;q11) translocation and its products

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Table 2. Cytogenetic and Hematologic Responses.

Recent survival of patients allografted for CML. Survival of 173 patients

While CML has been recognized since the late 1800's, it was the discovery of the Philadelphia chromosome in 1960 that changed the face of CML.

A genomic analysis of Philadelphia chromosome-negative AML arising in patients with CML | Blood Cancer Journal

The Translocation of t(9;22)(q34;q11) in CML.

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Figure 1: The Bone marrow karyotype of the patient showing three-way translocation, t(9;22;17), del(17p11.2) and secondary abnormalities viz. trisomy 8, ...

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Table 1. Base-Line Characteristics of the Patients.

Table 1. Hematologic Values and Results of Cytogenetic Analysis in the Patient.

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Kaplan–Meier Analysis of Progression-free Survival among Patients with CML or ALL Associated with Dasatinib.

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Peripheral Blood and Bone Marrow Findings in Patients With Blast Phase CML

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Autologous transplantation in chronic phase CML. Survival rate from

Figure 1. GTG-banding revealed a complex karyotype involving three chromosomes as well as the loss of the Y chromosome. All derivative chromosomes are ...

... product fusions using primers that map up and down stream of the breakpoints. For t(9;22) also nested PCR was performed. Sample legend: 1 – CML ...

The aMCB probe's unstained regions on the derivative chromosomes are shown in gray. #, chromosome; der, derivative chromosome; Ph, Philadelphia chromosome.

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Allogeneic transplantation in CML. Data shows survival from diagnosis

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Overview of Acute Leukemia

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Table 1. Characteristics of the Study Group.

Fig.1: (A-B): Chronic myeloid leukemia (CML) showing hypercellular

Figure 1

Cytogenetic analysis by G-banding identified 46,XX,t(9;22)(q34;q11.2).

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Analysis of peripheral blood lymphocytes from patients with CML at diagnosis and during treatment with tyrosine kinase inhibitors.

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Figure 1: Two photographic karyograms showing Variant Ph translocation t(7;9;22) in a patient with Chronic Myeloid Leukemia

(a) Peripheral blood smear at CML diagnosis demonstrating marked leukocytosis with granulocytic left shift and decreased platelets.

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Kaplan–Meier Estimates of the Rates of Event-free Survival and Progression to the Accelerated Phase or Blast Crisis of CML for Patients Receiving Imatinib.

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Simultaneous occurrence of a t(9;22) (Ph) with a t(2;11) in a patient with CML and emergence of a new clone with the t(2;11) alone after imatinib mesylate ...

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Effect of imatinib on apoptosis in CML and normal CD34+ cells treated with apoptosis-inducing agents. CML (n=4) and normal (n=3) CD34+ cells were exposed ...

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Figure 1: Two photographic karyograms showing Variant Ph translocation t (7;9;

Time to Progression to Accelerated Phase or Blast Phase of CML.

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status | Leukemia

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Signal transduction pathways involved in CML. Schematic representation of the cellular effects of BCR-

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Figures/Media

Isodicentric Philadelphia [idic(Ph)] chromosome in a case of CML at chronic phase Vundinti B R, Kerketta L, Korgaonkar S, Vaidya S, Ghosh K - Indian J ...

Metaphase showing translocation t(1;11)(q21;q23) and the add(9)(q34). The arrows indicate the chromosomes involved.

Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study | Leukemia

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... marrow cell showing (black arrows) the deleted part of the long arm of chromosome 22 translocated to the long arm of chromosome 9; t (9; 22) (q34; q11)

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(a) Cohort 1 representing CML patients who developed CCA in Ph-negative cells after TKI therapy. In three cases, where available, Ph-positive patient ...

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Table 1: Clinical details and cytogenetic results of the five cases

Figure 2: Illustration of t(9;22)(q34;q11.2), BCR-ABL1 fusion gene by FISH study. (a) Normal cell pattern, (b) Classical CML cell pattern, (c) Atypical ...

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Results

Table 2. Deaths during the Trial among Patients Randomly Assigned to Imatinib.

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A diagrammatic representation of the BCR and ABL1 genes swapping

Table 2 Karyotypic profile of 82 patients

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Figure 1 The median EFS of patients in CML-T group and CML-N group. Notes: The median EFS of patients in CML-T group was 21 months; however, the median EFS ...

Table 1. Baseline Characteristics of the Patients.

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Linear regression line (X-axis: % cells positive by FISH; Y-

5. Pathogenesis of CML ...

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Such cures presumably result from the combined effects of high dose chemotherapy and the graft-versus-leukaemia effect mediated by donor-derived T ...

Tyrosine Kinase Inhibitors upregulate stemness marker expression in Ph+ iPSCs clones. (a) Expression levels assessed by (miR)RT-qPCR of mature miRNAs302a/b, ...

Cytogenetic Studies During CML Blast Phase in Patients Treated in the Pre-TKI and TKI

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Table 4. Response to Ponatinib Treatment.

Patient disease status and clinical results for patients with SP-CML.